What is Desmopressin?

Desmopressin is a synthetic vasopressin V2-receptor analog first approved in 1978 for central diabetes insipidus, primary nocturnal enuresis, nocturia, and as a hemostatic agent in mild hemophilia A and von Willebrand disease. WADA prohibits it in sport at all times as a masking agent under Section S5.

Is Desmopressin approved for medical use?

Desmopressin is approved for one or more medical uses in at least one major jurisdiction. United States (FDA): Approved. First approved in 1978 (DDAVP); labelled indications include central diabetes insipidus, hemostasis in mild hemophilia A and von Willebrand disease, primary nocturnal enuresis, and nocturia due to nocturnal polyuria (Nocdurna). European Union (EMA): Authorized nationally across EU member states (not via a centralized EMA marketing authorisation). Australia (TGA): Registered on the ARTG (Minirin and other brands; tablet, nasal spray, sublingual wafer, and injection) for indications including diabetes insipidus and nocturnal enuresis; prescription medicine.

Is Desmopressin legal in Australia?

Desmopressin in Australia (TGA): Registered on the ARTG (Minirin and other brands; tablet, nasal spray, sublingual wafer, and injection) for indications including diabetes insipidus and nocturnal enuresis; prescription medicine.

Is Desmopressin banned in sport?

Desmopressin under the World Anti-Doping Agency (WADA) code: Prohibited at all times. Listed as a masking agent under Section S5 (Diuretics and Masking Agents) of the Prohibited List.

Synthetic vasopressin V2-receptor agonist analog (1-deamino-8-D-arginine vasopressin)

Desmopressin

Approvedaka DDAVP, 1-desamino-8-D-arginine vasopressin, Minirin, Stimate, Nocdurna, Noctiva

Desmopressin (DDAVP) is a long-established synthetic analog of the hormone vasopressin that concentrates urine and, at higher doses, raises factor VIII and von Willebrand factor to support clotting. It is approved by the FDA and TGA and authorized nationally across EU member states in nasal, oral, sublingual, and injectable forms. It is prohibited in sport by WADA as a masking agent.

Mechanism

In plain terms, desmopressin is a synthetic copy of a natural hormone that makes the kidneys hold onto water so the body produces less urine, and at higher doses it helps blood to clot. Technically, it is a synthetic analog of arginine vasopressin that is selective for the V2 receptor with minimal V1 (vasopressor) activity; V2 activation in the renal collecting ducts increases water reabsorption to produce antidiuresis, while it also releases stored factor VIII and von Willebrand factor from endothelium to support hemostasis.

Regulatory Status by Region

United States (FDA)Approved. First approved in 1978 (DDAVP); labelled indications include central diabetes insipidus, hemostasis in mild hemophilia A and von Willebrand disease, primary nocturnal enuresis, and nocturia due to nocturnal polyuria (Nocdurna).
Australia (TGA)Registered on the ARTG (Minirin and other brands; tablet, nasal spray, sublingual wafer, and injection) for indications including diabetes insipidus and nocturnal enuresis; prescription medicine.
European Union (EMA)Authorized nationally across EU member states (not via a centralized EMA marketing authorisation).
WADAProhibited at all times. Listed as a masking agent under Section S5 (Diuretics and Masking Agents) of the Prohibited List.

See the full regulatory status matrix

Key Studies

Landmark study of DDAVP in haemophilia and von Willebrand disease; Mannucci PM et al. (opens in a new tab) (Lancet 1977;1(8017):869-872; DOI 10.1016/s0140-6736(77)91197-7; PMID 67283)
Randomized double-blind placebo-controlled trial of low-dose desmopressin ODT for nocturia in men; Weiss JP et al. (opens in a new tab) (J Urol 2013;190(3):965-972; DOI 10.1016/j.juro.2012.12.112; PMID 23454402)

Related Clinical Trials

Latest research

Use of Desmopressin in Spontaneous Nontraumatic Intracerebral Hemorrhage Among Patients Taking Antiplatelet Therapy: Systematic Review and Bayesian Meta-analysis. (opens in a new tab)
Neurocritical care · Oct 12, 2026
Wendan decoction-derived TMF alleviates endolymphatic hydrops by modulating the DUSP3/p38 MAPK/AQP2 axis. (opens in a new tab)
Journal of ethnopharmacology · Oct 9, 2026
A Case of Misdiagnosed Pediatric Congenital Nephrogenic Diabetes Insipidus due to AQP2 Variants. (opens in a new tab)
Case reports in pediatrics · Oct 8, 2026
Copeptin and urine concentrating capacity predict kidney function decline in lithium-treated patients. (opens in a new tab)
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · Oct 8, 2026

See all recent Desmopressin research

Common Questions

What is Desmopressin?: Desmopressin is a synthetic vasopressin V2-receptor analog first approved in 1978 for central diabetes insipidus, primary nocturnal enuresis, nocturia, and as a hemostatic agent in mild hemophilia A and von Willebrand disease. WADA prohibits it in sport at all times as a masking agent under Section S5.
Is Desmopressin approved for medical use?: Desmopressin is approved for one or more medical uses in at least one major jurisdiction. United States (FDA): Approved. First approved in 1978 (DDAVP); labelled indications include central diabetes insipidus, hemostasis in mild hemophilia A and von Willebrand disease, primary nocturnal enuresis, and nocturia due to nocturnal polyuria (Nocdurna). European Union (EMA): Authorized nationally across EU member states (not via a centralized EMA marketing authorisation). Australia (TGA): Registered on the ARTG (Minirin and other brands; tablet, nasal spray, sublingual wafer, and injection) for indications including diabetes insipidus and nocturnal enuresis; prescription medicine.
How does Desmopressin work?: In plain terms, desmopressin is a synthetic copy of a natural hormone that makes the kidneys hold onto water so the body produces less urine, and at higher doses it helps blood to clot. Technically, it is a synthetic analog of arginine vasopressin that is selective for the V2 receptor with minimal V1 (vasopressor) activity; V2 activation in the renal collecting ducts increases water reabsorption to produce antidiuresis, while it also releases stored factor VIII and von Willebrand factor from endothelium to support hemostasis.
Is Desmopressin legal in Australia?: Desmopressin in Australia (TGA): Registered on the ARTG (Minirin and other brands; tablet, nasal spray, sublingual wafer, and injection) for indications including diabetes insipidus and nocturnal enuresis; prescription medicine.
Is Desmopressin banned in sport?: Desmopressin under the World Anti-Doping Agency (WADA) code: Prohibited at all times. Listed as a masking agent under Section S5 (Diuretics and Masking Agents) of the Prohibited List.